Music is defined as “vocal or instrumental sounds (or both) combined in such a way as to produce beauty of form, harmony, and expression of emotion.” Music has a great influence on man, from the womb to the last breath. Music can be created and enjoyed by all regardless of age, one’s socio-economic status, country of origin, religious beliefs, and ancestral heritage. The lecture starts with a brief write-up on Dr. Ephraim Amu in whose honour and memory the lecture was instituted by the Ghana Academy of Arts and Sciences in 1999.