Principally two main bodies conduct the Affairs of the Academy: The Council, which is the governing body, and the General meeting of Fellows. The Council comprises the Principal Officers of the Academy namely; the President, two Vice Presidents who are respectively the Chairpersons of the Science and Arts Sections, the Honorary Secretary and the Honorary Treasurer together with six other persons elected by the General Meeting of Fellows from among the Fellows of the Academy. The Council meets at least twice a year.
Prof. Kofi Opoku Nti, Game Theorist, Independent Consultant and former Dean of the University of Ghana Business School, Legon, as Vice President of the Arts Section;
Emerita Prof. Isabella Akyinbah Quakyi, Professor of Immunology and Parasitology and Foundation Dean of the School of Public Health (SPH), College of Health Sciences, University of Ghana (UG); 2014 Laureate of the prestigious African Union Kwame Nkrumah Award for Women in Science; Secretary-General, Network of African Science Academies (NASAC); and Member, Board of Ghana Nuclear Regulatory Authority, as Vice President of the Sciences Section;
Prof. Joseph Roland Atsu Ayee, Professor of Political Science; first Emeka Anyaoku Visiting Professor of Commonwealth Studies, University of London and a former Rector, MountCrest University College, Accra;
former Deputy Vice-Chancellor, University of KwaZulu-Natal, South Africa; appointed the UNESCO/United Nations University Leadership Chair at the University of Jordan from January – December 2001; Former Dean, Faculty of Social Studies, University of Ghana, Legon as Vice President of the Arts
Prof. Helen Atawube Yitah, Professor of English; Dean, the School of Languages, University of Ghana; former Head, Department of English, University of Ghana; founding Director, University of Ghana – Carnegie Writing Centre; Fellow, Columbia University Center for the Study of Social Difference and Chair, Publications Committee, GAAS, as the Honorary Secretary.
Prof. Lade Wosornu, Professor of Surgery (retired) and founding Fellow of the Ghana College of Surgeons; Member, Ghana Medical Association and West African College of Surgeons; Poet, Philanthropist, Essayist and Columnist for The Ghanaian Times, as Honorary Treasurer;
Rev. Prof. Johnson Kwabena Asamoah-Gyadu PhD, ordained minister of the Methodist Church Ghana; Baëta – Grau Professor of Contemporary African Christianity and Pentecostal/Charismatic Theology at the Trinity Theological Seminary, Accra, Ghana; and President, Trinity
Theological Seminary, Legon
Prof. Alfred Apau Oteng – Yeboah, retired Professor, Department of Plant and Environmental Biology, School of Biological Sciences, the University of Ghana; founding bureau member and former Vice-Chair of Intergovernmental science-policy Platform for Biodiversity and Ecosystem Services (IPBES), representing Africa; joint winner of the 2014 international prestigious Midori Prize for Biodiversity and Former Deputy Director-General of the Council for Scientific and Industrial Research (CSIR-Ghana)
Ben K. Ahunu, former Honorary Secretary, Professor of Animal Science; Founding Executive Member of the Ghana Society of Animal Production; former Provost of the College of Agriculture and Consumer Sciences, University of Ghana, Legon; Former Member of the Governing Council of the University of Ghana;
Professor Andrew Anthony Adjei, former Director of Research, Office of Research, Innovation and Development (ORID), Professor of Immunology at the University of Ghana School of Medicine and Dentistry (UGSMD); Department of Pathology) and the School of Biomedical and Allied Health Sciences (SBAHS), University of Ghana College of Health Sciences, Legon, former Deputy Provost of the College of Health Sciences, past President of the Ghana Association of Biomedical Laboratory Scientists and Fellow of the African Sciences Institute;
Professor Adams Bodomo, Professor of Linguistics and African Studies and the chair of African Languages and Literatures at the University of Vienna, Austria, President, the International Federation of Modern Languages and Literatures (FILLM), and Editor of the prestigious Journal of West African Languages
Emeritus Prof. Sefa-Dedeh was mandated to steer the affairs of the Academy for a two-year period from January 2021 to December 2022. He replaces Justice Prof. Henrietta J.A.N. Mensa-Bonsu, Justice of the Supreme Court of Ghana.